What these duos unlock
Seraphine performs best when allies extend the first window of control or damage. The strongest pairings on this page, such as Miss Fortune, Amumu, Caitlyn, create cleaner fights and more reliable tempo swings.
Synergies
Seraphine excels in dense AoE or teamfight compositions seeking to maximize her zone effects. She amplifies nearby allies through her passive double-cast and healing auras. Protect-the-carry or continuous poke compositions benefit from her hybrid kit.
Encore→
Beat Drop→
Bullet Time
Curse of the Sad Mummy→
Encore→
Beat Drop
Beat Drop→
Yordle Snap Trap→
Ace in the Hole
Cyclone→
Encore→
High NoteSeraphine performs best when allies extend the first window of control or damage. The strongest pairings on this page, such as Miss Fortune, Amumu, Caitlyn, create cleaner fights and more reliable tempo swings.
Seraphine has a support profile, so allies with CC Chain, Engage are usually the best fit. You often get the most value from partners played in ADC, Jungle.
These pairings matter most around first engage timing, objective setup, and follow-up on crowd control. The page is not just naming allies: it highlights combinations that reduce execution risk for Seraphine.
Miss Fortune is one of the strongest partners highlighted on this page because the duo creates cleaner engage or follow-up sequences for Seraphine.
Seraphine usually gains the most from allies who bring CC Chain. The goal is to make the first action easier to convert into damage, tempo, or objective control.
Strong duos such as Miss Fortune or Amumu matter, but not more than champion mastery. Use these synergies to refine a good draft, not to replace a pick you cannot execute.